• DocumentCode
    139094
  • Title

    Analysis of the HIV eradication phenomenon at the early stage of infection with an extracellular deterministic model

  • Author

    Chang, H. ; Moog, C.H. ; Astolfi, A.

  • Author_Institution
    Sch. of Electr. Eng., Kookmin Univ., Seoul, South Korea
  • fYear
    2014
  • fDate
    26-30 Aug. 2014
  • Firstpage
    330
  • Lastpage
    333
  • Abstract
    We investigate the phenomenon of HIV eradication at the early stage of the infection and evaluate the chance of the eradication with a mathematical model. We employ an extracellular deterministic model of the HIV infection dynamics and modify the model to include the pharmacokinetics and pharmacodynamics of antiretroviral HIV drugs. In addition we consider clinical experiments for the prevention of HIV infection using pre-exposure chemoprophylaxis treatment. Exploiting the mathematical model we implement the experiment numerically. The study in this paper is supported by the clinical results and provides a theoretical explanation for the results. The result suggests that the protocol of the experiment eradicates the virus in HIV infected patients.
  • Keywords
    cellular biophysics; drugs; microorganisms; numerical analysis; patient treatment; physiological models; HIV eradication phenomenon; HIV infected patients; HIV infection dynamics; HIV infection prevention; antiretroviral HIV drugs; extracellular deterministic model; mathematical model; numerical analysis; pharmacodynamics; pharmacokinetics; pre-exposure chemoprophylaxis treatment; Biological system modeling; Drugs; Human immunodeficiency virus; Immune system; Mathematical model; Numerical models; Protocols;
  • fLanguage
    English
  • Publisher
    ieee
  • Conference_Titel
    Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
  • Conference_Location
    Chicago, IL
  • ISSN
    1557-170X
  • Type

    conf

  • DOI
    10.1109/EMBC.2014.6943596
  • Filename
    6943596