Analysis of spontaneous MEG activity in mild cognitive impairment and Alzheimer´s disease using Jensen´s divergence

Author

Poza, Jesus ; Gomez, Christopher ; Garcia, M.A. ; Bachiller, Alejandro ; Fernandez, Alicia ; Hornero, Roberto

Author_Institution

Signal Theor. & Commun. Dept., Univ. of Valladolid, Valladolid, Spain

fYear

2014

fDate

26-30 Aug. 2014

Firstpage

1501

Lastpage

1504

Abstract

The aim of this study was to analyze the changes that mild cognitive impairment (MCI) and Alzheimer´s disease (AD) elicit in brain dynamics. For this task, the spontaneous magnetoencephalographic (MEG) activity from 36 AD patients, 18 MCI subjects and 24 healthy controls was analyzed. A disequilibrium measure, Jensen´s divergence, was used to estimate the irregularity of neural dynamics. Results revealed that AD patients displayed significant changes (p<;0.05) in the patterns of irregularity in comparison with MCI subjects and healthy controls. Slight differences between MCI subjects and elderly controls were also found. Our results suggest that AD progression is accompanied by region-specific patterns of abnormalities in the neural activity.

Keywords

bioelectric potentials; cognition; diseases; geriatrics; magnetoencephalography; neurophysiology; Alzheimer disease; Jensen divergence; brain dynamics; elderly controls; mild cognitive impairment; neural activity; region-specific patterns; spontaneous MEG activity analysis; spontaneous magnetoencephalographic activity analysis; Complexity theory; Dementia; Electroencephalography; Entropy; Sensors;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2014.6943886

Filename

6943886