Functional validation of an implantable medical dosing device by MRI at 3T

Author

Anderson, J.R. ; Ferrati, Silvia ; Karmonik, Chistof ; Grattoni, Alessandro

Author_Institution

MR Core Facilites, Houston Methodist Res. Inst., Houston, TX, USA

fYear

2014

fDate

26-30 Aug. 2014

Firstpage

2346

Lastpage

2347

Abstract

Sustained release of a small molecule from a prototype implantable drug delivery device was monitored via MRI in an ex vivo tissue phantom over a period of two days. T1 mapping was used as a method to quantify analyte concentration. Continuous, controlled release was observed. The MRI methodology was thus found to be appropriate for device validation and quality assurance/control.

Keywords

biochemistry; biodiffusion; biological tissues; biomedical MRI; chemical analysis; drug delivery systems; drugs; patient monitoring; phantoms; prosthetics; prototypes; quality assurance; quality control; MRI; T1 mapping; analyte concentration quantification; continuous controlled release; ex vivo tissue phantom; implantable drug delivery device; implantable medical dosing device; magnetic flux density 3 T; medical dosing device functional validation; prototype; quality assurance; quality control; small molecule release monitoring; sustained release monitoring; time 2 day; Containers; Drug delivery; Implants; Magnetic resonance imaging; Phantoms;

fLanguage

English

Publisher

ieee

Conference_Titel

Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE

Conference_Location

Chicago, IL

ISSN

1557-170X

Type

conf

DOI

10.1109/EMBC.2014.6944091

Filename

6944091