Title :
Halloysite nanotube-based drug delivery system for treating osteosarcoma
Author :
Lin Sun ; Mills, David K.
Author_Institution :
Sch. of Biol. Sci., Louisiana Tech Univ., Ruston, LA, USA
Abstract :
Our previous studies have shown that halloysite nanotubes (HNTs) can be doped with a variety of bioactive agents (antibiotics, growth factors, chemotherapeutics) and the agents can be released in a sustained manner. In this study, anti-tumor drugs were loaded into HNTs and tested for their ability to inhibit/kill osteosarcoma cells. Results demonstrate that drugs released from the HNTs can inhibit proliferation or induce apoptosis in the osteosarcoma cells showing the potential application of doped HNTs as an anti-cancer drug delivery system.
Keywords :
biomedical materials; cancer; cellular biophysics; drug delivery systems; drugs; nanomedicine; nanotubes; tumours; antibiotics; anticancer drug delivery system; antitumor drug delivery system; bioactive agents; chemotherapeutics; growth factors; halloysite nanotube-based drug delivery system; osteosarcoma cell apoptosis; osteosarcoma cell proliferation; Drug delivery; Drugs; Educational institutions; Nanobioscience; Polymers; Tumors;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/EMBC.2014.6944234
