DocumentCode
139997
Title
Halloysite nanotube-based drug delivery system for treating osteosarcoma
Author
Lin Sun ; Mills, David K.
Author_Institution
Sch. of Biol. Sci., Louisiana Tech Univ., Ruston, LA, USA
fYear
2014
fDate
26-30 Aug. 2014
Firstpage
2920
Lastpage
2923
Abstract
Our previous studies have shown that halloysite nanotubes (HNTs) can be doped with a variety of bioactive agents (antibiotics, growth factors, chemotherapeutics) and the agents can be released in a sustained manner. In this study, anti-tumor drugs were loaded into HNTs and tested for their ability to inhibit/kill osteosarcoma cells. Results demonstrate that drugs released from the HNTs can inhibit proliferation or induce apoptosis in the osteosarcoma cells showing the potential application of doped HNTs as an anti-cancer drug delivery system.
Keywords
biomedical materials; cancer; cellular biophysics; drug delivery systems; drugs; nanomedicine; nanotubes; tumours; antibiotics; anticancer drug delivery system; antitumor drug delivery system; bioactive agents; chemotherapeutics; growth factors; halloysite nanotube-based drug delivery system; osteosarcoma cell apoptosis; osteosarcoma cell proliferation; Drug delivery; Drugs; Educational institutions; Nanobioscience; Polymers; Tumors;
fLanguage
English
Publisher
ieee
Conference_Titel
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location
Chicago, IL
ISSN
1557-170X
Type
conf
DOI
10.1109/EMBC.2014.6944234
Filename
6944234
Link To Document