Responses to transients in living and simulated neurons

Author

Stiber, Michael ; Ieong, Ricci ; Segundo, J.P.

Author_Institution

Dept. of Molecular & Cell Biol., California Univ., Berkeley, CA, USA

Volume

8

Issue

6

fYear

1997

fDate

11/1/1997 12:00:00 AM

Firstpage

1379

Lastpage

1385

Abstract

This paper is concerned with synaptic coding when inputs to a neuron change over time. Experiments were performed on a living and simulated embodiment of a prototypical inhibitory synapse. These were used to test a simple model composed of a fixed delay preceding a nonlinear encoder. Based on these results, we present a qualitative model for phenomena previously observed in the living preparation, including hysteresis and dependence of discharge regularity on rate of change of presynaptic spike rate. As change is the rule rather than the exception in nature, understanding neurons responses to nonstationarity is essential for understanding their function

Keywords

encoding; muscle; neural nets; neurophysiology; nonlinear systems; physiological models; transient response; discharge regularity; dynamics; hysteresis; living neurons; muscles; neuromuscular stimulation; nonlinear encoder; nonlinear systems; presynaptic spike rate; simulated neurons; synaptic coding; transient response; Acceleration; Biological system modeling; Delay; Muscles; Neurons; Pacemakers; Prototypes; Testing; Timing; Virtual prototyping;

fLanguage

English

Journal_Title

Neural Networks, IEEE Transactions on

Publisher

ieee

ISSN

1045-9227

Type

jour

DOI

10.1109/72.641461

Filename

641461