Tapered metal microneedles fabricated by the hybrid process of mechanical dicing and electrochemical corrosion for drug delivery

Author

Xiao-Xiao Yan ; Jing-Quan Liu ; Shui-Dong Jiang ; Bin Yang ; Chun-Sheng Yang

Author_Institution

Nat. Key Lab. of Sci. & Technol. on Nano/Micro Fabrication, Shanghai Jiao Tong Univ., Shanghai, China

Volume

7

Issue

12

fYear

2012

fDate

12/1/2012 12:00:00 AM

Firstpage

1313

Lastpage

1315

Abstract

Metal microneedles are fabricated by the process of cutting and electrochemical corrosion. The fabricated microneedles are 400 m in length, 700 m in space and have sharp tapered tips. In a force test, these microneedles could penetrate an artificial skin and a rat s skin well and safely. In a vitro transdermal drug delivery test, the amount of the permeated flux of calcein and of the bovine serum albumin through the treated rat skin increased by 35 and six times than that on the intact skin, respectively.

Keywords

corrosion; cutting; drug delivery systems; drugs; electrochemistry; microfabrication; molecular biophysics; needles; proteins; skin; artificial skin; bovine serum albumin; calcein; cutting; electrochemical corrosion; hybrid process; intact skin; mechanical dicing; permeated flux; rat skin; sharp tapered tips; size 400 mum; size 700 mum; tapered metal microneedles; vitro transdermal drug delivery testing;

fLanguage

English

Journal_Title

Micro & Nano Letters, IET

Publisher

iet

ISSN

1750-0443

Type

jour

DOI

10.1049/mnl.2012.0633

Filename

6419622