DocumentCode :
140413
Title :
Electrophysiological properties under heart failure conditions in a human ventricular cell: A modeling study
Author :
Elshrif, Mohamed M. ; Pengcheng Shi ; Cherry, Elizabeth M.
Author_Institution :
B. Thomas Golisano Coll. of Comput. & Inf. Sci., Rochester Inst. of Technol., Rochester, NY, USA
fYear :
2014
fDate :
26-30 Aug. 2014
Firstpage :
4324
Lastpage :
4329
Abstract :
Heart failure (HF) is one of the major diseases across the world. During HF the electrophysiology of the failing heart is remodeled, which renders the heart more susceptible to ventricular arrhythmias. In this study, we quantitatively analyze the effects of electrophysiological remodeling of the major currents of human ventricular myocytes on the dynamics of the failing heart. We develop a HF model using a modified version of a recently published model of the human ventricular action potential, the O´Hara-Virag-Varro-Rudy (OVVR) model. The proposed HF model incorporates recently available HF clinical data. It can reproduce most of the action potential (AP) properties of failing myocytes, including action potential duration (APD), amplitude (APA), notch (APN), plateau (APP), resting membrane potential (RMP), and maximum upstroke velocity (dV/dtmax). In addition, the model reproduces the behavior of the [Na+], concentration and [Ca2+]i dynamics. Moreover, the HF model exhibits alternans with a fast pacing frequency and can induce early afterdepolarizations (EADs). Additionally, blocking the late sodium current shortens the APD and suppresses EADs, in agreement with experimental findings. The dynamics of the proposed model are assessed through investigating the rate dependence of the AP and the dynamics of the major currents. The steady-state (S-S) and S1-S2 restitution curves along with accommodation to an abrupt change in cycle length were evaluated. Our study should help to elucidate the roles of alterations in electrophysiological properties during HF. Also, this HF cellular model could be used to study HF in a realistic geometry and could be embedded into a model of HF electromechanics to investigate electrical and mechanical properties simultaneously during HF.
Keywords :
bioelectric potentials; biomechanics; biomembrane transport; cardiovascular system; cellular biophysics; diseases; physiological models; sodium; APA; APD; APN; APP; EAD; HF cellular model; HF clinical data; HF electromechanics; HF model; O´Hara-Virag-Varro-Rudy model; OVVR; RMP; S1-S2 restitution curves; [Ca2+]i dynamics; [Na+] behavior; action potential amplitude; action potential duration; action potential notch; action potential plateau; action potential properties; alternans; concentration; cycle length; diseases; early after depolarizations; electrical properties; electrophysiological properties; electrophysiological remodeling; electrophysiology; failing heart dynamics; failing myocytes; fast pacing frequency; heart failure conditions; human ventricular action potential; human ventricular cell; human ventricular myocytes; late sodium current; major current dynamics; major currents; maximum upstroke velocity; mechanical properties; modeling study; rate dependence; realistic geometry; resting membrane potential; steady-state restitution curves; ventricular arrhythmias; Biological system modeling; Calcium; Data models; Hafnium; Heart; Mathematical model; Protocols;
fLanguage :
English
Publisher :
ieee
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
ISSN :
1557-170X
Type :
conf
DOI :
10.1109/EMBC.2014.6944581
Filename :
6944581
Link To Document :
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