Title :
Microwave treatments for prostate disease
Author :
Sterzer, Fred ; Mendecki, Jozef ; Mawhinney, Daniel D. ; Friedenthal, Esther ; Melman, Arnold
Author_Institution :
MMTC Inc., Princeton, NJ, USA
fDate :
11/1/2000 12:00:00 AM
Abstract :
Describes three novel microwave techniques that show promise for being useful in treating diseases of the prostate. They are: microwave urethroplasty for providing immediate symptomatic relief of urinary obstructions caused by benign prostatic hypertrophy-this technique uses microwave balloon catheters for producing biological stems in the urethra. Initial results obtained in an Federal Drug Administration approved Phase I clinical trial are highly encouraging, hyperthermia produced in the prostate by dual microwave balloon catheters-when combined with external beam radiation or implanted radioactive seeds, this technique has the potential of improving local recurrence rates of prostate cancer over the rates that are obtained when only radiation treatments are given, and microwave poration therapy-a therapy that, when combined with either systemic or locally administered chemotherapy, has been shown to be effective in shrinking implanted prostatic tumors in rats. The potential clinical advantages of microwave poration/chemotherapy over electrochemotherapy using dc pulses for treating cancers are discussed.
Keywords :
biological organs; cancer; diseases; hyperthermia; microwave heating; radiation therapy; DC pulses; benign prostatic hypertrophy; biological stems in urethra; cancer treatment; immediate symptomatic relief; implanted prostatic tumors shrinking; implanted radioactive seeds; local recurrence rates; locally administered chemotherapy; microwave balloon catheters; microwave poration therapy; microwave treatments; microwave urethroplasty; potential clinical advantages; prostate disease; rats; urinary obstructions; Catheters; Clinical trials; Diseases; Drugs; Hyperthermia; Medical treatment; Microwave theory and techniques; Neoplasms; Prostate cancer; Rats;
Journal_Title :
Microwave Theory and Techniques, IEEE Transactions on