Title :
Optical Clearing for OCT Image Enhancement and In-Depth Monitoring of Molecular Diffusion
Author :
Larin, Kirill V. ; Ghosn, M.G. ; Bashkatov, A.N. ; Genina, E.A. ; Trunina, Natalia A. ; Tuchin, Valery V.
Author_Institution :
Univ. of Houston, Houston, TX, USA
Abstract :
In this paper, we overview the basic principles, recent results, advantages, limitations, and future of the optical clearing method in application to many fields of biology and medicine. We also discuss the possibility of noninvasive assessment of molecular diffusion in tissues using the optical coherence tomography technique. Issues of safety and toxicity of application of different endogenous and exogenous molecules to tissues are outlined.
Keywords :
biodiffusion; biological tissues; biomedical optical imaging; molecular biophysics; optical tomography; OCT image enhancement; endogenous molecules; exogenous molecules; in depth molecular diffusion monitoring; optical clearing agent safety; optical clearing agent toxicity; optical clearing method; optical coherence tomography; tissue molecular diffusion noninvasive assessment; Biomedical optical imaging; Blood; Optical imaging; Optical refraction; Optical scattering; Refractive index; Molecular diffusion; optical clearing; optical coherence tomography;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/JSTQE.2011.2181991
