Title :
Simultaneous stimulation and recording of cardiac depolarization enabled by high-frequency stimulation
Author :
Giovangrandi, Laurent
Author_Institution :
Electr. Eng. Dept., Stanford Univ., Stanford, CA, USA
Abstract :
High-frequency stimulation techniques have been recently proposed for the pacing and control of excitability of cardiac tissues. This paper introduces a system designed specifically for such stimulation, and demonstrates the unique ability to record depolarization events on the same electrode used for stimulation, during the stimulus. Experimental results with HL-1 cardiomyocytes are presented, highlighting key concepts enabled by this system, such as direct strength-duration relationship measurement and beat-to-beat stimulation threshold monitoring following pacing onset or pharmacological modulation.
Keywords :
bioelectric potentials; biomedical electrodes; cardiology; muscle; patient treatment; polarisation; HL-1 cardiomyocytes; beat-to-beat stimulation threshold monitoring; cardiac depolarization recording; cardiac depolarization stimulation; cardiac tissue excitability control; cardiac tissue excitability pacing; direct strength-duration relationship measurement; electrode; high-frequency stimulation techniques; pharmacological modulation; Band-pass filters; Electric potential; Electrical stimulation; Electrodes; Monitoring; Noise; Passive filters;
Conference_Titel :
Engineering in Medicine and Biology Society (EMBC), 2014 36th Annual International Conference of the IEEE
Conference_Location :
Chicago, IL
DOI :
10.1109/EMBC.2014.6945110
