Title :
A Simulation Tool to Study High-Frequency Chest Compression Energy Transfer Mechanisms and Waveforms for Pulmonary Disease Applications
Author :
O´Clock, George D. ; Yong Wan Lee ; Lee, Jongwon ; Warwick, Warren J.
Author_Institution :
Med. Sch., Dept. of Pediatrics, Univ. of Minnesota, Minneapolis, MN, USA
fDate :
7/1/2010 12:00:00 AM
Abstract :
High-frequency chest compression (HFCC) can be used as a therapeutic intervention to assist in the transport and clearance of mucus and enhance water secretion for cystic fibrosis patients. An HFCC pump-vest and half chest-lung simulation, with 23 lung generations, has been developed using inertance, compliance, viscous friction relationships, and Newton´s second law. The simulation has proven to be useful in studying the effects of parameter variations and nonlinear effects on HFCC system performance and pulmonary system response. The simulation also reveals HFCC waveform structure and intensity changes in various segments of the pulmonary system. The HFCC system simulation results agree with measurements, indicating that the HFCC energy transport mechanism involves a mechanically induced pulsation or vibration waveform with average velocities in the lung that are dependent upon small air displacements over large areas associated with the vest-chest interface. In combination with information from lung physiology, autopsies and a variety of other lung modeling efforts, the results of the simulation can reveal a number of therapeutic implications.
Keywords :
biomedical equipment; biomedical measurement; diseases; lung; patient treatment; physiological models; pneumodynamics; vibrations; HFCC half chest-lung simulation; HFCC pump-vest simulation; HFCC waveform structure; Newton second law; cystic fibrosis; energy transfer mechanisms; high-frequency chest compression; lung modeling; lung physiology; mechanically induced pulsation; mucus; pulmonary disease; pulmonary system response; small air displacements; therapeutic intervention; vest-chest interface; vibration waveform; viscous friction; water secretion; Energy transport mechanism; high-frequency chest compression (HFCC); inelastic momentum; pulmonary disease; trapezoidal waveform; Chest Wall Oscillation; Computer Simulation; Exhalation; Lung; Lung Diseases; Models, Biological; Nonlinear Dynamics; Signal Processing, Computer-Assisted;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2010.2041453
