A MRI and Polarized Gases Compatible Respirator and Gas Administrator for the Study of the Small Animal Lung: Volume Measurement and Control

Author

Kyriazis, Angelos ; De Alejo, Rigoberto Perez ; Rodriguez, Ignacio ; Olsson, Lars E. ; Ruiz-Cabello, Jesus

Author_Institution

Inst. de Estudios Biofuncionales, Univ. Complutense de Madrid, Madrid, Spain

Volume

57

Issue

7

fYear

2010

fDate

7/1/2010 12:00:00 AM

Firstpage

1745

Lastpage

1749

Abstract

We have developed over the past years an experimental magnetic resonance imaging (MRI) and polarized gases compatible mechanical respirator for the study of the small experimental animal. The respirator has been successfully used for experiments both in the MRI setting for polarized ³He, ¹⁹F, and proton imaging as well as for functional measurements of the lungs. The new main pneumatic valve with the two integrated sensors for simultaneous lung pressure and volume measurements and the proportional valve to set the tidal volume of the respiration are described. It is shown how the device measures and controls the tidal volume of the lungs.

Keywords

biomedical MRI; lung; pneumodynamics; pressure measurement; volume control; volume measurement; MRI; gas administrator; lung pressure measurement; lung volume control; lung volume measurement; magnetic resonance imaging; pneumatic valve; polarized gases compatible respirator; proton imaging; small animal lung; Animal studies; magnetic resonance imaging (MRI); mechanical respiration; polarized gases; pulmonary studies; Animals; Biomedical Research; Gases; Lung Compliance; Lung Volume Measurements; Magnetic Resonance Imaging; Mice; Ventilators, Mechanical;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2010.2042596

Filename

5416290