Towards a Healthy Human Model of Neural Disorders of Movement

Author

Poizner, Howard ; Lancaster, Jeff ; Tunik, Eugene ; Narayana, Srinivas ; Franklin, C. ; Rogers, W. ; Xiaoyan Li ; Fox, Peter T. ; Robin, D.A.

Author_Institution

Inst. for Neural Comput., Univ. of California-San Diego, La Jolla, CA, USA

Volume

20

Issue

6

fYear

2012

Firstpage

853

Lastpage

857

Abstract

A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.

Keywords

biomechanics; biomedical MRI; brain; kinematics; neurophysiology; transcranial magnetic stimulation; 3D movement kinematics; TMS; clinical disorders; event-related fMRI; healthy human model; image-guided; linking motor neuroscience; motor function; neural disorders; simultaneous recording; transcranial magnetic stimulation; virtual-lesion physiology; Humans; Kinematics; Magnetic resonance imaging; Neuroimaging; Three dimensional displays; Apraxia; brain imaging; kinematics; motor control; Adult; Biomechanics; Cerebral Cortex; Data Interpretation, Statistical; Female; Gait Disorders, Neurologic; Hand; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Motor Skills; Movement; Neuronavigation; Psychomotor Performance; Transcranial Magnetic Stimulation; User-Computer Interface;

fLanguage

English

Journal_Title

Neural Systems and Rehabilitation Engineering, IEEE Transactions on

Publisher

ieee

ISSN

1534-4320

Type

jour

DOI

10.1109/TNSRE.2012.2184769

Filename

6138324