PG-ISFET based DNA-logic for reaction monitoring

Author

Wong, Wing Kee ; Georgiou, Pantelis ; Ou, C.-P. ; Toumazou, Christofer

Author_Institution

Inst. of Biomed. Eng., Imperial Coll. London, London, UK

Volume

46

Issue

5

fYear

2010

Firstpage

330

Lastpage

332

Abstract

A report on the use of programmable gate-ion sensitive field effect transistors (PG-ISFETs) to form DNA-logic gates for reaction monitoring is presented. A PG-ISFET sensor is integrated with standard MOSFETs to form a chemical-inverter that switches when a chemical reaction reaches a certain threshold. By employing feedback to the electrical gate rapid switching is achieved for changes in pH as low as 0.1 units, overcoming limitations of voltage division owing to passivation capacitance of CMOS based ISFETs. Using this, DNA-logic arrays can be synthesised to carry out highly parallel chemical processing functions for applications such as DNA sequencing.

Keywords

MOSFET; chemical reactions; chemical sensors; circuit feedback; ion sensitive field effect transistors; logic arrays; logic gates; CMOS; DNA-logic arrays; DNA-logic gates; MOSFET; PG-ISFET; chemical reaction; chemical-inverter; electrical gate rapid switching; feedback; parallel chemical processing; passivation capacitance; programmable gate-ion sensitive field effect transistors; reaction monitoring;

fLanguage

English

Journal_Title

Electronics Letters

Publisher

iet

ISSN

0013-5194

Type

jour

DOI

10.1049/el.2010.3463

Filename

5426966