Title :
Gold microelectrode arrays with monolithically-integrated circuits for label-free monitoring of bio-molecule interaction in-situ
Author :
Yu-Chieh Lee ; Hsin Chen
Author_Institution :
Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan
Abstract :
This paper presents a CMOS chip integrating EGFETs (extended-gate field-effect transistors) with gold microelectrodes for label-free monitoring of the DNA amplification. The accumulation of intrinsic charges of DNAs causes the surface potential of microelectrodes to change gradually, and the potential change is detected by the readout circuit integrated with the microelectrodes. A second-order Bessel low pass filter is further employed to eliminate both high-frequency noise and ground interferences.
Keywords :
CMOS integrated circuits; DNA; amplification; biochemistry; biological techniques; biomedical electrodes; biomedical electronics; field effect transistors; gold; low-pass filters; microelectrodes; molecular biophysics; monolithic integrated circuits; readout electronics; Au; CMOS chip integrating EGFET; DNA amplification; extended-gate field-effect transistors; gold microelectrode arrays; ground interferences; high-frequency noise; in-situ biomolecule interaction; intrinsic charges; label-free monitoring; monolithically-integrated circuits; second-order Bessel low pass filter; DNA; Electric potential; Gold; Logic gates; Microelectrodes; Monitoring; Noise; DNA sensing; Gold electrodes; label-free detection;
Conference_Titel :
Bioelectronics and Bioinformatics (ISBB), 2014 IEEE International Symposium on
Conference_Location :
Chung Li
Print_ISBN :
978-1-4799-2769-2
DOI :
10.1109/ISBB.2014.6820921
