Gold microelectrode arrays with monolithically-integrated circuits for label-free monitoring of bio-molecule interaction in-situ

Author

Yu-Chieh Lee ; Hsin Chen

Author_Institution

Dept. of Electr. Eng., Nat. Tsing Hua Univ., Hsinchu, Taiwan

fYear

2014

fDate

11-14 April 2014

Firstpage

1

Lastpage

4

Abstract

This paper presents a CMOS chip integrating EGFETs (extended-gate field-effect transistors) with gold microelectrodes for label-free monitoring of the DNA amplification. The accumulation of intrinsic charges of DNAs causes the surface potential of microelectrodes to change gradually, and the potential change is detected by the readout circuit integrated with the microelectrodes. A second-order Bessel low pass filter is further employed to eliminate both high-frequency noise and ground interferences.

Keywords

CMOS integrated circuits; DNA; amplification; biochemistry; biological techniques; biomedical electrodes; biomedical electronics; field effect transistors; gold; low-pass filters; microelectrodes; molecular biophysics; monolithic integrated circuits; readout electronics; Au; CMOS chip integrating EGFET; DNA amplification; extended-gate field-effect transistors; gold microelectrode arrays; ground interferences; high-frequency noise; in-situ biomolecule interaction; intrinsic charges; label-free monitoring; monolithically-integrated circuits; second-order Bessel low pass filter; DNA; Electric potential; Gold; Logic gates; Microelectrodes; Monitoring; Noise; DNA sensing; Gold electrodes; label-free detection;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioelectronics and Bioinformatics (ISBB), 2014 IEEE International Symposium on

Conference_Location

Chung Li

Print_ISBN

978-1-4799-2769-2

Type

conf

DOI

10.1109/ISBB.2014.6820921

Filename

6820921