Vectorcardiographic loop alignment and morphologic beat-to-beat variability

The measurement of subtle morphologic beat-to-beat variations in the electrocardiogram is complicated by the presence of respiration-induced movements of the heart. A statistical signal model is developed which accounts for such movements by means of scaling, rotation, and time synchronization of vector-cardiographic loops. The maximum-likelihood estimator of the parameters describing these three transformations is presented and is extended to the case of multiple loop alignment. The performance of the method is assessed by measuring morphologic variability before and after loop alignment. It is shown that the effects of respiration on morphologic variability can be considerably reduced by the new method. Measurements on morphologic variability were typically reduced by a factor of 0.53 after loop alignment. The results show also that beat-to-beat measurements are strongly dependent on the selected sampling rate and that a rate of 1 kHz is too low.