Novel In Vitro and In Vivo Neural Interfaces: Normal and Accelerated Failure Assessment

Author

Otto, Kevin J. ; Williams, Justin C.

Author_Institution

Dept. of Biol. Sci., Purdue Univ., West Lafayette, IN, USA

Volume

3

Issue

1

fYear

2012

Firstpage

27

Lastpage

29

Abstract

The in vitro acute brain slice test bed offers the advantages of natural configurations and proportions of cells and tissues. As a function of time, electrode insertion activates signaling pathways in microglia, astrocytes, and neurons that result in biochemical changes that alter the biophysical characteristics of the tissue.Temperature- modulated acceleration, based onthe Arrhenius equation, is a common method to predict the lifetime of samples.

Keywords

biomedical electrodes; brain-computer interfaces; failure analysis; life testing; neurophysiology; Arrhenius equation; astrocytes; biochemical changes; brain slice test bed; electrode insertion; failure assessment; microglia; neural interfaces; neurons; signaling pathways; temperature- modulated acceleration; Biological tissues; Central nervous system; Implantable biomedical devices; Implants; Injuries; Neuroscience; Pathology; Animals; Bioengineering; Electrodes, Implanted; Humans; Models, Neurological; Nerve Net; Signal Transduction; User-Computer Interface;

fLanguage

English

Journal_Title

Pulse, IEEE

Publisher

ieee

ISSN

2154-2287

Type

jour

DOI

10.1109/MPUL.2011.2175631

Filename

6153120