Title :
Magnetic Microactuator for Controlling Nanoparticles in Gene Delivery Applications
Author :
Flick, Eva ; Belski, Alexander ; Li, Wenzhong ; Steinhoff, Gustav ; Gatzen, Hans H.
Author_Institution :
Center for Production Technol., Leibniz Univ. Hannover, Garbsen, Germany
Abstract :
Magnetic force-enhanced gene delivery provides a promising method for an efficient transfection even to single cells. Conjugating genes with magnetic nanoparticles allows for the magnetic manipulation of these complexes. This paper presents the concept, modeling, and fabrication technology for a magnetic microactuator designed as a pole row for magnetically actuating these complexes. For conducting preliminary tests, a scaled-up model of the micro pole row was created.
Keywords :
bioMEMS; cellular biophysics; electromagnetic actuators; gene therapy; magnetic particles; medical control systems; microactuators; microfabrication; nanoparticles; fabrication technology; magnetic force-enhanced gene delivery; magnetic manipulation; magnetic microactuator design; magnetic nanoparticle control; micro pole row; single cell transfection; Magnetic MEMS; microactuator; single stem cell transfection; thin-film technology;
Journal_Title :
Magnetics, IEEE Transactions on
DOI :
10.1109/TMAG.2009.2025669
