Integrated Optical Coherence Tomography (OCT) and Fluorescence Laminar Optical Tomography (FLOT)

Author

Chen, Yu ; Yuan, Shuai ; Wierwille, Jeremiah ; Naphas, Renee ; Li, Qian ; Blackwell, Tiffany R. ; Winnard, Paul T., Jr. ; Raman, Venu ; Glunde, Kristine

Author_Institution

Fischell Dept. of Bioeng., Univ. of Maryland, College Park, MD, USA

Volume

16

Issue

4

fYear

2010

Firstpage

755

Lastpage

766

Abstract

Multimodal imaging represents one of the current trends in the development of biophotonics imaging technologies. This paper briefly reviews current multimodal biophotonics imaging platforms in macroscopic, microscopic, and mesoscopic (or millimeter) scales. We also present a combined optical coherence tomography and line-scan fluorescence laminar optical tomography system for co-registered structural and molecular imaging with millimeter-scale imaging depth. Experimental results using a capillary phantom filled with the fluorescence dye Cy5.5 and a human breast cancer xenograft model are presented.

Keywords

bio-optics; cancer; fluorescence; optical tomography; phantoms; Cy5.5; FLOT; OCT; biophotonics imaging technologies; capillary phantom; co-registered structural imaging; fluorescence dye; fluorescence laminar optical tomography; human breast cancer xenograft model; integrated optical coherence tomography; molecular imaging; multimodal imaging; Fluorescence laminar optical tomography (FLOT); multimodality imaging; optical coherence tomography (OCT);

fLanguage

English

Journal_Title

Selected Topics in Quantum Electronics, IEEE Journal of

Publisher

ieee

ISSN

1077-260X

Type

jour

DOI

10.1109/JSTQE.2009.2037723

Filename

5438778