Towards Treatment Planning for the Embolization of Arteriovenous Malformations of the Brain: Intranidal Hemodynamics Modeling

Author

Orlowski, Piotr ; Al-Senani, Fahmi ; Summers, Paul ; Byrne, James ; Noble, J. Alison ; Ventikos, Yiannis

Author_Institution

Dept. of Eng. Sci., Univ. of Oxford, Oxford, UK

Volume

58

Issue

7

fYear

2011

fDate

7/1/2011 12:00:00 AM

Firstpage

1994

Lastpage

2001

Abstract

This paper presents a patient-derived model for the simulation of the hemodynamics of arteriovenous malformations of the brain (BAVM). This new approach is a step toward the simulation of the outcome of the embolization of the BAVM during treatment planning. More specifically, two aspects of the planning are pursued: simulation of the change of blood flow in the brain vasculature after the blocking of the malformation and simulation of the transport of the embolic liquid. The method we propose is tested on 3 BAVM cases of varying complexity. Twenty two out of 24 main BAVM flow paths have been identified well by simulation.

Keywords

biotransport; blood vessels; brain; diagnostic radiography; haemodynamics; medical image processing; patient treatment; physiological models; arteriovenous malformations; blood flow; brain; brain vasculature; embolic liquid transport; embolization; intranidal hemodynamics modeling; patient-derived model; Arteries; Blood; Equations; Permeability; Phantoms; Veins; Viscosity; Arteriovenous malformation of the brain; cerebrovascular image analysis; computational fluid dynamics; embolization; neurointerventions; Algorithms; Computer Simulation; Embolization, Therapeutic; Hemodynamics; Humans; Intracranial Arteriovenous Malformations; Models, Cardiovascular; Therapy, Computer-Assisted; Viscosity;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/TBME.2011.2119317

Filename

5720283