Design features and performance of a CsI(Na) array based gamma camera for small animal gene research

Author

Weisenberger, A.G. ; Kross, B. ; Majewski, S. ; Wojlck, R. ; Bradley, E.L. ; Saha, M.S.

Author_Institution

Detector Group, Thomas Jefferson Nat. Accelerator Facility, Newport News, VA, USA

Volume

45

Issue

6

fYear

1998

fDate

12/1/1998 12:00:00 AM

Firstpage

3053

Lastpage

3058

Abstract

The authors report on the development and performance of a radiation imaging system based on a 110 mm diameter matrix of 1 mm×1 mm size CsI(Na) scintillating crystals. This detector system has been optimized for high resolution radiation imaging of the distribution of iodine 125 (¹²⁵I) in a laboratory animal. The radioisotope ¹²⁵I is readily available as a label to molecular biology probes that can be used in gene research. The system utilizes the Hamamatsu 5 inch diameter 3292 position sensitive photomultiplier tube (PSPMT) coupled to the CsI(Na) matrix and a custom built high resolution copper-beryllium collimator. A resulting spatial resolution of the order of 1.5 mm FWHM and a sensitivity of 68 cpm/μCi were obtained with the copper-beryllium collimator. The detector system is installed on a rotating gantry to obtain multiple projections and is now being used in animal studies

Keywords

biological techniques; caesium compounds; cameras; genetics; image resolution; photomultipliers; radioisotope imaging; sodium; solid scintillation detectors; 110 mm; 5 in; CsI(Na) array based gamma camera; CsI(Na) matrix; CsI:Na; Cu-Be; Hamamatsu 5 inch diameter 3292 position sensitive photomultiplier tube; I; animal studies; biological research instrumentation; camera design features; camera performance; custom built high resolution copper-beryllium collimator; laboratory animal; multiple projections; rotating gantry; small animal gene research; spatial resolution; Animals; Collimators; Crystals; Image resolution; Laboratories; Probes; Radiation detectors; Radiation imaging; Radioactive materials; Spatial resolution;

fLanguage

English

Journal_Title

Nuclear Science, IEEE Transactions on

Publisher

ieee

ISSN

0018-9499

Type

jour

DOI

10.1109/23.737663

Filename

737663