Title :
A high-sensitivity micromachined biosensor
Author :
Baselt, David R. ; Lee, Gil U ; Hansen, Karolyn M. ; Chrisey, Linda A. ; Colton, Richard J.
Author_Institution :
Naval Res. Lab., Washington, DC, USA
fDate :
4/1/1997 12:00:00 AM
Abstract :
The Force Amplified Biological Sensor (FABS) is a desktop or portable instrument currently under development at the Naval Research Laboratory. FABS will use a rapid, automated immunoassay to detect analytes such as proteins, viruses, and bacteria. The assay uses forces produced by micron-sized magnetic particles to pull on antibody-antigen bonds. Microfabricated piezoresistive cantilevers measure the resulting piconewton-level forces with sufficient sensitivity to detect single antibody-antigen bonds. These forces also serve to characterize the bonds, allowing FABS to distinguish specific antibody-antigen bonds from nonspecific interactions
Keywords :
biosensors; magnetic particles; magnetic sensors; micromachining; microsensors; piezoresistive devices; analyte detection; antibody-antigen bonds; automated immunoassay; bacteria; desktop instrument; force amplified biological sensor; magnetic particles; micromachined biosensor; nonspecific interactions; piezoresistive cantilever; portable instrument; proteins; viruses; Biosensors; Force sensors; Immune system; Instruments; Laboratories; Magnetic analysis; Magnetic particles; Microorganisms; Proteins; Viruses (medical);
Journal_Title :
Proceedings of the IEEE
