Investigation of Extracellular Signal Shapes Recorded by Planar Metal Microelectrodes Covered With Carbon Nanotubes: Modeling and Simulations

Author

Massobrio, Giuseppe ; Massobrio, Paolo ; Martinoia, Sergio

Author_Institution

Dept. of Biophys. & Electron. Eng., Univ. of Genova, Genoa, Italy

Volume

10

Issue

6

fYear

2011

Firstpage

1328

Lastpage

1336

Abstract

Bundles of carbon nanotubes (CNTs) arranged in vertical alignment and in normal direction to the surface of a planar metal microelectrode were used to interface neurons and the recording microtransducer. A model of such a hybrid system was developed and implemented in HSPICE to simulate and analyze the electrical interactions and the induced extracellularly recorded neuronal electrical activity as a function of the neuroelectronic junction and CNTs bundle parameters. The results pointed out carbon nanotubes, as electrical interfaces to neurons, act both on the amplitude and the shape of the recorded signals.

Keywords

bioelectric phenomena; biomedical electrodes; biomedical electronics; biomedical transducers; carbon nanotubes; cellular biophysics; microelectrodes; nanoelectronics; neurophysiology; C; CNT bundle parameters; HSPICE; carbon nanotubes; electrical interaction; electrical interfaces; extracellular signal shapes; hybrid system; interface neurons; neuroelectronic junction; neuronal electrical activity; planar metal microelectrodes; recording microtransducer; Carbon nanotubes; Integrated circuit modeling; Microelectrodes; Neurons; Quantum capacitance; Resistance; Carbon nanotube; HSPICE simulation; extracellular signal recording; microelectrode; neuroelectronic junction; neuron;

fLanguage

English

Journal_Title

Nanotechnology, IEEE Transactions on

Publisher

ieee

ISSN

1536-125X

Type

jour

DOI

10.1109/TNANO.2011.2138716

Filename

5743020