Title :
Effect of Cell Geometry on Conduction Velocity in a Subcellular Model of Myocardium
Author :
Toure, Amadou ; Cabo, Candido
Author_Institution :
Dept. of Biomed. Eng., City Univ. of New York, New York, NY, USA
Abstract :
We have studied the effect of cell geometry on propagation velocity of the cardiac impulse using a subcellular computer model of myocardium. Variation of cell size has only small effects on longitudinal and transverse conduction velocities, when the ratio of cell length/width is constant, for cell sizes (length X width) between (60 μm × 20 μm) and (120 μm × 40 μm). The results were not dependent on gap-junction conductance (range 0.25-1 μS), gap-junction distribution, or the specific tissue architecture. Longitudinal conduction velocity increased with the cell length/width ratio and transverse velocity decreased. The cell length/width ratio was a good estimator of the anisotropic ratio. In conclusion, cell length/width ratio is more important than cell size in determining conduction velocity.
Keywords :
bioelectric phenomena; cardiovascular system; cellular biophysics; muscle; physiological models; anisotropic ratio; cardiac impulse; cell geometry; cell length-width ratio; cell size; conductance 0.25 muS to 1.0 muS; longitudinal conduction velocity; myocardium; propagation velocity; size 120 mum; size 20 mum; size 40 mum; size 60 mum; subcellular computer model; tissue architecture; transverse conduction velocity; Bioelectric phenomena; cardiovascular system; modeling; simulation; Animals; Anisotropy; Cell Shape; Cell Size; Cells, Cultured; Computer Simulation; Dogs; Electric Conductivity; Electrophysiological Phenomena; Gap Junctions; Heart Conduction System; Models, Cardiovascular; Myocardium;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
DOI :
10.1109/TBME.2010.2050064
