Preparation of degradable polymeric nanocapsules from hyperbranched poly (amine ester) grafted nanosilica templates

A facile approach for the preparation of degradable crosslinked polymeric nanocapsules with hydroxyl functional groups was developed by polycondensation from the nanosilica templates. The hyperbranched poly (amine ester) grafted silica nanoparticles (SN-HPAE) were crosslinked with hexamethylene diisocyanate (HDI). Then the silica templates were removed by HF etching to produce the degradable polymeric nanocapsules. The inner diameter of polymeric nanocapsules is in the range of 20-100-nm, which is characterised by transmission electron microscopy (TEM). The strategy developed was confirmed with Fourier transform infrared, thermogravimetric analysis and TEM.