Title :
Feedback control of a biodynamical model of HIV-1
Author :
Brandt, Michael E. ; Chen, Guanrong
Author_Institution :
Health & Sci. Center, Texas Univ., Houston, TX, USA
fDate :
7/1/2001 12:00:00 AM
Abstract :
Describes a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. The authors demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. They also show how the immune system components can be bolstered against the virus through a feedback control approach.
Keywords :
biocontrol; blood; differential equations; diseases; feedback; microorganisms; patient treatment; physiological models; CD4 lymphocytes; CD8 lymphocytes; HIV-1; biodynamical model; continuous differential equation model; feedback control; human body; immune system components bolstering; stable control methods; therapeutic drug regimen; virus; white blood cells; Biological system modeling; Blood; Capacitive sensors; Differential equations; Drugs; Feedback control; Human immunodeficiency virus; Immune system; Medical treatment; Plasma measurements; Acquired Immunodeficiency Syndrome; Anti-HIV Agents; CD4-CD8 Ratio; Disease Progression; Feedback; HIV-1; Half-Life; Humans; Models, Biological; Nonlinear Dynamics; Viral Load;
Journal_Title :
Biomedical Engineering, IEEE Transactions on
