Feedback control of a biodynamical model of HIV-1

Author

Brandt, Michael E. ; Chen, Guanrong

Author_Institution

Health & Sci. Center, Texas Univ., Houston, TX, USA

Volume

48

Issue

7

fYear

2001

fDate

7/1/2001 12:00:00 AM

Firstpage

754

Lastpage

759

Abstract

Describes a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. The authors demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. They also show how the immune system components can be bolstered against the virus through a feedback control approach.

Keywords

biocontrol; blood; differential equations; diseases; feedback; microorganisms; patient treatment; physiological models; CD4 lymphocytes; CD8 lymphocytes; HIV-1; biodynamical model; continuous differential equation model; feedback control; human body; immune system components bolstering; stable control methods; therapeutic drug regimen; virus; white blood cells; Biological system modeling; Blood; Capacitive sensors; Differential equations; Drugs; Feedback control; Human immunodeficiency virus; Immune system; Medical treatment; Plasma measurements; Acquired Immunodeficiency Syndrome; Anti-HIV Agents; CD4-CD8 Ratio; Disease Progression; Feedback; HIV-1; Half-Life; Humans; Models, Biological; Nonlinear Dynamics; Viral Load;

fLanguage

English

Journal_Title

Biomedical Engineering, IEEE Transactions on

Publisher

ieee

ISSN

0018-9294

Type

jour

DOI

10.1109/10.930900

Filename

930900