Keynote: Personalized medicine enabled by FSC.X technology

In the first stage of developing combinatorial drugs for treating disease, the current approach is to identify the aberrant targets molecule in the complex cellular network of signaling and regulatory pathways. We then need to find drugs for guiding the bio complex systems toward a desired state. Both tasks are ??finding needles in hays stacks??. Rather than laboriously mapping out the detailed cascade of various pathways, our approach is to employ a feedback system control (FSC.X) scheme to bypass the challenges associated with simultaneously considering/manipulating multiple cellular pathways. In addition, we have harnessed these control schemes to rationally design combinatorial drug therapy modalities to stimulate the bio systems with improved efficacy and low toxicity. This imposes another challenge which pertains to the large parameter space. For example, N drugs with C concentrations each would result in CN potential search trials. With the feedback system optimization approach, we have demonstrated that only tens of searches instead of CN cases are needed to identify the optimized drug cocktail.