Keynote: Toward Brain-Machine Interfaces for diagnostic and treatment of complex neural diseases

Emerging Brain-Machine Interfaces for diagnostic and recovery of neural vital functions are promising alternative to study neural activities underlying cognitive functions and pathologies. This talk covers circuit techniques and Microsystems intended for intracortical neurorecording and neurostimulation. Special attention will be paid to multidimensional design and implementation challenges such as power management, low-power circuit design, high-data rate communication modules, and reliable wireless energy and data transmission will be described. Case studies of continuous EcoG recording intended for learning about the intracortical vision mechanism, and adaptive spike detection intended for onset epileptic seizure focus localization and treatment will be described. In addition, microstimulation strategies in the primary visual cortex, which is intended to recover vision for the blind through multisite large arrays of microelectrodes will be reported. Finally, Lab-on-chip (LoC) based neurotransmitters detection, manipulation and characterization intended for diagnostic purposes to locate dysfunctions at the level of neural cells interconnections will be summarized.