Integrated Bimodal Waveguide Interferometric Biosensor for Label-Free Analysis

Author

Zinoviev, Kirill E. ; González-Guerrero, Ana Belén ; Domínguez, Carlos ; Lechuga, Laura M.

Author_Institution

Micro & Nanosystems Dept., Inst. de Microelectron. de Barcelona, Barcelona, Spain

Volume

29

Issue

13

fYear

2011

fDate

7/1/2011 12:00:00 AM

Firstpage

1926

Lastpage

1930

Abstract

The performance of an interferometric device based on integrated Bimodal Waveguides (BiMW) for sensing is demonstrated. The sensors are fabricated using standard silicon technology and can achieve a detection limit of 2.5·10^{- 7} RIU for homogeneous sensing, rendering in a very high sensitive device. The applicability of the bimodal waveguide interferometer as label-free biosensor has been demonstrated by the real-time monitoring of the biomolecular interaction of BSA and antiBSA. Due to their simplicity, the interferometric devices could be further integrated in complete lab-on-a-chip platforms for point-of-care diagnostics showing them as a powerful instrument for biochemical analysis.

Keywords

biochemistry; biosensors; lab-on-a-chip; biochemical analysis; homogeneous sensing; integrated bimodal waveguide interferometric biosensor; lab-on-a-chip; label-free analysis; standard silicon technology; Biosensors; Optical interferometry; Optical sensors; Optical waveguides; Refractive index; Temperature sensors; Bimodal waveguide; evanescent wave detection; integrated optics; optical biosensors; waveguides;

fLanguage

English

Journal_Title

Lightwave Technology, Journal of

Publisher

ieee

ISSN

0733-8724

Type

jour

DOI

10.1109/JLT.2011.2150734

Filename

5765416