Title :
Dual-molecule spectroscopy: molecular rulers for the study of biological macromolecules
Author :
Ha, T. ; Enderle, Th. ; Chemla, D.S. ; Weiss, S.
Author_Institution :
Div. of Mater. Sci., Lawrence Berkeley Lab., CA, USA
fDate :
12/1/1996 12:00:00 AM
Abstract :
Single-molecule detection and spectroscopy by laser induced fluorescence offer many applications to life sciences. We review recent techniques and experiments based on the detection and spectroscopy of two near-by molecules. The spectroscopic signature of the light emitted from the two molecules can be used to measure the distance, orientation and relative dynamics between biological macromolecules
Keywords :
biological techniques; fluorescence spectroscopy; intramolecular mechanics; molecular biophysics; molecular configurations; optical microscopy; reviews; biological macromolecules; distance; dual-molecule spectroscopy; fluorescence resonance energy transfer; molecular rulers; near field scanning optical microscope; orientation; relative dynamics; review; spectroscopic signature; two near-by molecules; Biomedical optical imaging; Chemical lasers; Fluorescence; Laser excitation; Laser theory; Molecular biophysics; Optical microscopy; Probes; Spectroscopy; Surface emitting lasers;
Journal_Title :
Selected Topics in Quantum Electronics, IEEE Journal of
DOI :
10.1109/2944.577342
