Title :
Contactless dielectrophoretic manipulation of biological cells using pulsed magnetic fields
Author :
Novickij, Vitalij ; Grainys, Audrius ; Novickij, Jurij
Author_Institution :
High Magn. Field Lab., Vilnius Gediminas Tech. Univ., Vilnius, Lithuania
Abstract :
Contactless method for manipulation of polar or polarisable micro and nanoscale particles based on the dielectrophoresis force exerted by the induced electric field in high pulsed magnetic field is presented in this study. Finite element method analysis of the magnetic and resulting induced electric fields is carried out. The structure of the magnetic field generator that was based on a controlled frequency spark gap, and the structure of the coil that was used as a load are described. Experimental data showing positive dielectrophoresis on the Jurkat T-lymphoblasts is presented. The study discusses further developments of the technique, its limitations and possible applications.
Keywords :
biological effects of fields; biological techniques; biomagnetism; cellular effects of radiation; coils; electrophoresis; finite element analysis; nanoparticles; spark gaps; Jurkat T-lymphoblasts; biological cells; coil structure; contactless dielectrophoretic manipulation; contactless method; dielectrophoresis force; finite element method analysis; frequency spark gap; induced electric field; magnetic field generator structure; nanoscale particle manipulation; polar particle manipulation; polarisable microparticle manipulation; positive dielectrophoresis; pulsed magnetic fields;
Journal_Title :
Nanobiotechnology, IET
DOI :
10.1049/iet-nbt.2012.0039