Design of integrated microfluidic device for sorting magnetic beads in biological assays

Author

Tondra, Mark ; Granger, Mike ; Fuerst, Rachel ; Porter, Marc ; Nordman, Catherine ; Taylor, John ; Akou, Seraphin

Author_Institution

NVE Corp., Eden Prairie, MN, USA

Volume

37

Issue

4

fYear

2001

fDate

7/1/2001 12:00:00 AM

Firstpage

2621

Lastpage

2623

Abstract

On-chip manipulation of nanoscopic magnetic particles in microfluidic channels has been demonstrated. The particles, obtained from Bangs Labs, were 460 nm in diameter and contained 12% ferrite. They were moving in a 12 μm wide by 4 μm deep channel etched into a deposited layer of silicon nitride. An Al current strap was buried beneath the channel and shaped in such a way to generate an in-plane cross-channel field gradient when it was energized by an electrical current. An in-plane external field of 20 kA/m was applied in order to magnetize the particles. They were observed to move across the channel as either the current or field polarity was changed

Keywords

biological techniques; magnetic particles; microfluidics; Al; Si₃N₄; aluminum current strap; biological assay; magnetic bead sorting; magnetic field gradient; microfluidic device; nanoscopic ferrite particles; silicon nitride layer; Fractionation; Instruments; Magnetic devices; Magnetic fields; Magnetic separation; Magnetization; Microfluidics; Micromagnetics; Permanent magnets; Sorting;

fLanguage

English

Journal_Title

Magnetics, IEEE Transactions on

Publisher

ieee

ISSN

0018-9464

Type

jour

DOI

10.1109/20.951254

Filename

951254