• DocumentCode
    1532853
  • Title

    Three-Class ROC Analysis—Toward a General Decision Theoretic Solution

  • Author

    He, Xin ; Gallas, Brandon D. ; Frey, Eric C.

  • Author_Institution
    Sch. of Med., Dept. of Radiol., Johns Hopkins Univ., Baltimore, MD, USA
  • Volume
    29
  • Issue
    1
  • fYear
    2010
  • Firstpage
    206
  • Lastpage
    215
  • Abstract
    Multiclass receiver operating characteristic (ROC) analysis has remained an open theoretical problem since the introduction of binary ROC analysis in the 1950s. Previously, we have developed a paradigm for three-class ROC analysis that extends and unifies decision theoretic, linear discriminant analysis, and probabilistic foundations of binary ROC analysis in a three-class paradigm. One critical element in this paradigm is the equal error utility (EEU) assumption. This assumption allows us to reduce the intrinsic space of the three-class ROC analysis (5-D hypersurface in 6-D hyperspace) to a 2-D surface in the 3-D space of true positive fractions (sensitivity space). In this work, we show that this 2-D ROC surface fully and uniquely provides a complete descriptor for the optimal performance of a system for a three-class classification task, i.e., the triplet of likelihood ratio distributions, assuming such a triplet exists. To be specific, we consider two classifiers that utilize likelihood ratios, and we assumed each classifier has a continuous and differentiable 2-D sensitivity-space ROC surface. Under these conditions, we proved that the classifiers have the same triplet of likelihood ratio distributions if and only if they have the same 2-D sensitivity-space ROC surfaces. As a result, the 2-D sensitivity surface contains complete information on the optimal three-class task performance for the corresponding likelihood ratio classifier.
  • Keywords
    biomedical imaging; decision theory; sensitivity analysis; 5D hypersurface; 6D hyperspace; decision theoretic solution; equal error utility; likelihood ratio distribution; receiver operating characteristic analysis; three class ROC analysis; three class paradigm; Biomedical imaging; Linear discriminant analysis; Malignant tumors; Mammography; Medical diagnosis; Medical diagnostic imaging; Myocardium; Neoplasms; Radiology; Extended receiver operating characteristic (ROC) analysis; ROC analysis; three-class ROC analysis; Algorithms; Decision Support Techniques; Diagnostic Imaging; Humans; Image Processing, Computer-Assisted; ROC Curve;
  • fLanguage
    English
  • Journal_Title
    Medical Imaging, IEEE Transactions on
  • Publisher
    ieee
  • ISSN
    0278-0062
  • Type

    jour

  • DOI
    10.1109/TMI.2009.2034516
  • Filename
    5306177