Title :
Influence of radioactivity out of the field of view on 3D PET dynamic measurement with [11C]MP4A
Author :
Hasegawa, T. ; Suzuki, M. ; Murayama, II ; Irie, Takasuke ; Fukushi, K. ; Wada, Y.
Author_Institution :
Sch. of Allied Health Sci., Kitasato Univ., Sagamihara, Japan
fDate :
8/1/1999 12:00:00 AM
Abstract :
This study assessed the influence of radioactivity out of the field of view (out-of-FOV) on the measurement of brain acetylcholinesterase (AChE) activity with the tracer [11C]N-methyl-4-piperidyl-acetate by positron emission tomography in three-dimensional mode. Dynamic scans on a volunteer showed that the out-of-FOV radioactivity in the chest was much higher than that of the brain immediately after tracer injection. A representative phantom measurement was performed to quantitate the systematic errors due to the out-of-FOV radioactivity. Resultant errors in the AChE activity (k3 parameter) as calculated by compartment model analysis were found to be less than one percent in all of the brain regions studied
Keywords :
brain; positron emission tomography; radioactivity; 3D PET dynamic measurement; C; [11C]MP4A; brain acetylcholinesterase activity; brain regions; compartment model analysis; medical diagnostic imaging; nuclear medicine; out-of-field-of-view radioactivity influence; representative phantom measurement; systematic errors; Large Hadron Collider; Liver; Lungs; Positron emission tomography;
Journal_Title :
Nuclear Science, IEEE Transactions on
