Disposable bio-microfluidic package with passive fluidic control

Author

Xie, Ling ; Chong, Ser Choong ; Premachandran, C.S. ; Pinjala, D. ; Iyer, Madadevan K.

Author_Institution

Inst. of Microelectron., Singapore

Volume

1

fYear

2005

Abstract

A disposable bio-microfluidic package has been developed for DNA (deoxyribonucleic acid) extraction applications. Low cost material such as PDMS (polydimethylsiloxane) is used for the encapsulation of the microfluidic chip. A network of microchannels and passive valves are formed on the PDMS by casting or soft lithography technique. They control the flow sequence of reagents in line with DNA extraction protocol. Encapsulation of the chip is done by bonding two layers PDMS substrates fabricated by acrylic mold. Plasma treatment with additional heating at 80 degC on PDMS surface enhances the bonding strength of PDMS to chip. Passive valves with different dimensions have been fabricated and characterized for different flow rates. A microfluidic package with passive valves has been developed to control the fluidic flow in microchannels with threshold pressure

Keywords

DNA; encapsulation; genetics; microchannel flow; microvalves; soft lithography; 80 C; DNA extraction applications; PDMS surface; disposable bio-microfluidic package; microchannels; microfluidic chip encapsulation; passive fluidic control; passive valves; plasma treatment; polydimethylsiloxane; soft lithography; Biological materials; Bonding; Costs; DNA; Encapsulation; Fluid flow control; Microchannel; Microfluidics; Packaging; Valves;

fLanguage

English

Publisher

ieee

Conference_Titel

Electronic Packaging Technology Conference, 2005. EPTC 2005. Proceedings of 7th

Conference_Location

Singapore

Print_ISBN

0-7803-9578-6

Type

conf

DOI

10.1109/EPTC.2005.1614373

Filename

1614373