In vivo investigation of DMSA-coated magnetic fluid

Author

Lacava, Z.G.M. ; Chaves, S.B. ; Lacava, L.M. ; Morais, P.C. ; Garcia, V.A.P. ; Silva, O. ; Pelegrini, F. ; Buske, N. ; Gansau, C. ; Curi, R. ; Azevedo, R.B.

Author_Institution

Instituto de Biologia, Brasilia Univ., Brazil

fYear

2002

Abstract

Summary form only given. Magnetic fluids (MFs) have been used as a promising technological basis for biomedical applications. In the present study a biocompatible magnetic fluid (BMF) sample is given as an intravenous bolus dose to mice. Magnetic resonance (MR) and light microscopy (LM) are used to investigate the biodistribution of the nanomagnetic-based material over several organs and the time-decay of the BMF sample in the blood circulation, up to four hours after injection. The BMF sample used in this study contains magnetite nanoparticles surface-coated with DMSA to obtain a stable sample at physiological pH and salinity.

Keywords

biomagnetism; biomedical materials; ferrites; magnetic fluids; magnetic particles; magnetic resonance; nanoparticles; optical microscopy; organic compounds; DMSA-coated magnetic fluid; Fe/sub 3/O/sub 4/; biocompatible magnetic fluid; biodistribution; biomedical applications; in vivo investigation; intravenous bolus dose; light microscopy; magnetic resonance; magnetite nanoparticles; mice; organs; time-decay; Biological materials; Biomedical materials; In vivo; Magnetic force microscopy; Magnetic liquids; Magnetic materials; Magnetic resonance; Mice; Nanoparticles; Nanostructured materials;

fLanguage

English

Publisher

ieee

Conference_Titel

Magnetics Conference, 2002. INTERMAG Europe 2002. Digest of Technical Papers. 2002 IEEE International

Conference_Location

Amsterdam, The Netherlands

Print_ISBN

0-7803-7365-0

Type

conf

DOI

10.1109/INTMAG.2002.1000988

Filename

1000988