Title :
A miniature CMOS optoelectronic biosensor for screening skin-whitening agents
Author :
Yu-Wei Chang ; Lu, Yen-Pei ; Lin, Ming-Yu ; Huang, Yang-Tung ; Yang, Yuh-Shyong
Author_Institution :
Inst. of Electron., Nat. Chiao Tung Univ., Hsinchu
Abstract :
A miniature CMOS optoelectronic biosensor is proposed for screening whitening agents. Based on the principle of absorption photometry, this biosensor is mainly composed of a green LED, a CMOS phototransistor, and a slide for performing the biochemical reactions. The requirement of the sample volume is only 10 mul, much less than those in commercial instruments. Melanin assay and MTT assay were performed to evaluate the whitening mechanisms. Experimental results demonstrated that the density of 5times104 cells/ml can be successfully detected for both assays. This portable biosensor has great potential toward personalized diagnostic kits for further applications.
Keywords :
CMOS integrated circuits; bio-optics; biochemistry; chemical sensors; integrated optoelectronics; light emitting diodes; optical sensors; patient diagnosis; phototransistors; skin; CMOS phototransistor; LED; MTT assay; absorption photometry; biochemical reactions; melanin assay; miniature CMOS optoelectronic biosensor; personalized diagnostic kits; screening skin-whitening agents; Absorption; Biomedical optical imaging; Biosensors; CMOS technology; Cells (biology); Instruments; Malignant tumors; Optical variables control; Photometry; Phototransistors;
Conference_Titel :
Bioengineering Conference, 2009 IEEE 35th Annual Northeast
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4362-8
Electronic_ISBN :
978-1-4244-4364-2
DOI :
10.1109/NEBC.2009.4967712
