Title :
A miniaturized AC magnetic susceptometer for detecting biomolecules tagged to magnetic nanoparticles
Author :
Kyoungchul Park ; Sonkusale, Sameer ; Guertin, R.P. ; Harrah, T. ; Goldberg, Edward B.
Author_Institution :
Dept. of Electr. & Comput. Eng., Tufts Univ., Medford, MA
Abstract :
We demonstrate a miniaturized AC magnetic susceptometer to detect biomolecules tagged to magnetic nanoparticles (MNPs). The proposed compact susceptometer measures the magnetic relaxation spectrum of biomolecules tagged with MNPs in an aqueous suspension. The relaxation time corresponds to the Brownian relaxation time and depends on the hydrodynamic size of the MNPs. Conventional susceptometers are bulky, expensive and are designed for extreme conditions (e.g. low temperature or high DC magnetic field). Our handheld prototype is composed of AC current source, precise millimeter sized differential sensing coils, and a ultra-sensitive lock-in amplifier. The performances were verified for 15, 25 nm Fe3O4-COOH MNPs suspended in solution. The result for each sample show the peak frequency of imaginary susceptibility is inversely proportional to effective hydrodynamic size of MNPs.
Keywords :
Brownian motion; amplifiers; iron compounds; magnetic particles; magnetic relaxation; magnetic sensors; molecular biophysics; nanobiotechnology; nanoparticles; suspensions; AC current source; Brownian relaxation time; Fe3O4-COOH; aqueous suspension; compact susceptometer; handheld prototype; hydrodynamic size; imaginary susceptibility; magnetic nanoparticles; magnetic relaxation spectrum; miniaturized AC magnetic susceptometer; precise millimeter sized differential sensing coils; size 15 nm; size 25 nm; tagged biomolecules; ultrasensitive lock-in amplifier; Amplifiers; Coils; Hydrodynamics; Magnetic field measurement; Magnetic levitation; Magnetic susceptibility; Molecular biophysics; Nanoparticles; Prototypes; Temperature sensors;
Conference_Titel :
Bioengineering Conference, 2009 IEEE 35th Annual Northeast
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4362-8
Electronic_ISBN :
978-1-4244-4364-2
DOI :
10.1109/NEBC.2009.4967761
