The influence of surface morphology and rigidity of the substrata on cell motility

Author

Chen, W.C. ; Hsieh, P.C. ; Wang, G.M. ; Yeh, M.L.

Author_Institution

Inst. of Biomed. Eng., Nat. Cheng Kung Univ., Tainan

fYear

2009

Firstpage

1

Lastpage

2

Abstract

Physical factors like stiffness and surface morphology of the substrata are thought to influence cell behaviors. How the cell motility at early attachment influenced by the substrates was not investigated yet. The purpose of this study is to measure the cell motility under different stiffness and pattern of the substrata. PDMS groups moved significant faster than glass due to smaller stiffness. In addition, over 80% of cells on long groove PDMS moved along the groove, indicating long groove was the best surface morphology to control cell directional movement.

Keywords

biocontrol; biomechanics; cell motility; polymers; shear modulus; surface morphology; PDMS group; cell directional movement control; cell motility; cell stiffness; polydimethlsiloxane substrate; substrata pattern; surface morphology; Atomic force microscopy; Atomic measurements; Cancer; Cells (biology); Glass; Micromechanical devices; Optical microscopy; Scanning electron microscopy; Surface morphology; Surface topography; Cell motility; MEMS; PDMS; Substrate rigidity; Surface morphology;

fLanguage

English

Publisher

ieee

Conference_Titel

Bioengineering Conference, 2009 IEEE 35th Annual Northeast

Conference_Location

Boston, MA

Print_ISBN

978-1-4244-4362-8

Electronic_ISBN

978-1-4244-4364-2

Type

conf

DOI

10.1109/NEBC.2009.4967790

Filename

4967790