Title :
The influence of surface morphology and rigidity of the substrata on cell motility
Author :
Chen, W.C. ; Hsieh, P.C. ; Wang, G.M. ; Yeh, M.L.
Author_Institution :
Inst. of Biomed. Eng., Nat. Cheng Kung Univ., Tainan
Abstract :
Physical factors like stiffness and surface morphology of the substrata are thought to influence cell behaviors. How the cell motility at early attachment influenced by the substrates was not investigated yet. The purpose of this study is to measure the cell motility under different stiffness and pattern of the substrata. PDMS groups moved significant faster than glass due to smaller stiffness. In addition, over 80% of cells on long groove PDMS moved along the groove, indicating long groove was the best surface morphology to control cell directional movement.
Keywords :
biocontrol; biomechanics; cell motility; polymers; shear modulus; surface morphology; PDMS group; cell directional movement control; cell motility; cell stiffness; polydimethlsiloxane substrate; substrata pattern; surface morphology; Atomic force microscopy; Atomic measurements; Cancer; Cells (biology); Glass; Micromechanical devices; Optical microscopy; Scanning electron microscopy; Surface morphology; Surface topography; Cell motility; MEMS; PDMS; Substrate rigidity; Surface morphology;
Conference_Titel :
Bioengineering Conference, 2009 IEEE 35th Annual Northeast
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4362-8
Electronic_ISBN :
978-1-4244-4364-2
DOI :
10.1109/NEBC.2009.4967790
