Title :
A novel tissue engineering electrospun-PLGA for potential application in tendon repair
Author :
Chen, J.P. ; Yeh, Mei-Ling ; Nien, Y.H.
Author_Institution :
Inst. of Biomed. Eng., Nat. Cheng Kung Univ., Tainan
Abstract :
The treatment of the rupture tendon is still an obstacle in respect of suture method. Therefore, such shortcoming in repairing fracture tendons could be overcome through tissue engineering approaches. The aim of present study is to investigate the influence of processing parameters on PLGA scaffold morphology and fiber diameters and the effect of the tendon fibroblast with the obtained novel tissue engineering electrospun-PLGA. The nanofiber scaffold was produced via electrospinning. The result shows that the nanofiber diameter and morphology could be controlled under different processing parameters. The Achilles tendon fibroblasts exhibit enough cell viability and were attached with spindle shape on the PLGA nanofiber scaffold. Therefore, PLGA nanofiber scaffold have the potential for Achilles tendon repair.
Keywords :
biomechanics; biomedical materials; bone; cellular biophysics; electrospinning; nanobiotechnology; nanofibres; polymers; tissue engineering; Achilles tendon fibroblasts; PLGA scaffold morphology; cell viability; electrospun-PLGA; fiber diameters; nanofiber scaffold; suture method; tendon repair; tissue engineering; Biological materials; Biomedical engineering; Chemical technology; Fibroblasts; Morphology; Optical fiber testing; Scanning electron microscopy; Tendons; Tissue engineering; Voltage; PLGA nanofiber; electrospinning; tendon fibroblasts; tissue engineering;
Conference_Titel :
Bioengineering Conference, 2009 IEEE 35th Annual Northeast
Conference_Location :
Boston, MA
Print_ISBN :
978-1-4244-4362-8
Electronic_ISBN :
978-1-4244-4364-2
DOI :
10.1109/NEBC.2009.4967803
