Title :
Rapid electronic prediction of gene expression regulation in bacterial cells
Author :
Alam, Shahinur ; Lai, E.M.-K. ; Young, James ; Hasan, S. M. Rezaul
Author_Institution :
Sch. of Eng. & Adv. Technol., Massey Univ., Auckland, New Zealand
Abstract :
A cytomorphic circuit that can mimic gene expression regulation mechanisms is presented. It is shown that this circuit can efficiently predict the cellular response of the bacterium Escherichia coli in real time. The simulation outputs of the circuit are compared with biological experimental results. The significant similarity between these results shows that the circuit can be used to predict cellular malfunctioning within microseconds.
Keywords :
cellular biophysics; genetics; microorganisms; Escherichia coli bacterium; bacterial cells; cellular malfunctioning; cellular response; cytomorphic circuit; gene expression regulation; microseconds; rapid electronic prediction; real time;
Journal_Title :
Electronics Letters
DOI :
10.1049/el.2014.2144