An acoustic plate mode device for biosensor applications

Author

Andle, J.C. ; Vetelino, J.F. ; Lade, M.W. ; McAllister, D.J.

Author_Institution

Dept. of Electr. Eng., Maine Univ., Orono, ME, USA

fYear

1991

Firstpage

483

Lastpage

485

Abstract

Experimental data are presented which show that the dual delay line interferometer consisting of SH-APM (shear horizontal acoustic plate mode) devices is a sensitive analytical tool potentially capable of detecting subnanogram per millimeter quantities of a specific DNA sequence without interference from thermal drift or nonspecific DNA sequences. The APM biosensor was tested with DNA polymers and showed a measurable response at the nanogram level per millimeter of solution. The biosensor is reusable and qualitatively reproducible.<>

Keywords

DNA; acoustic wave interferometers; biosensors; surface acoustic wave devices; ultrasonic delay lines; DNA sequence; acoustic plate mode device; biosensor applications; dual delay line interferometer; qualitatively reproducible; reusable; shear horizontal acoustic plate mode; subnanogram per millimeter quantities; Acoustic applications; Acoustic devices; Acoustic signal detection; Acoustic testing; Biosensors; DNA; Delay lines; Interference; Millimeter wave devices; Sequences;

fLanguage

English

Publisher

ieee

Conference_Titel

Solid-State Sensors and Actuators, 1991. Digest of Technical Papers, TRANSDUCERS '91., 1991 International Conference on

Conference_Location

San Francisco, CA, USA

Print_ISBN

0-87942-585-7

Type

conf

DOI

10.1109/SENSOR.1991.148917

Filename

148917