Title :
Decreased Lempel-Ziv complexity in Alzheimer´s disease patients´ magnetoencephalograms
Author :
Gómez, Carlos ; Hornero, Roberto ; Abásolo, Daniel ; López, Miguel ; Fernández, Alberto
Author_Institution :
E.T.S. Ingenieros de Telecomunicacion, Valladolid Univ.
Abstract :
The aim of the present research is to study the magnetoencephalogram (MEG) background activity in patients with Alzheimer´s disease (AD) using the Lempel-Ziv (LZ) complexity. We recorded the MEG with a 148-channel whole-head magnetometer (MAGNES 2500 WH, 4D Neuroimaging) in 10 patients with probable AD and 10 age-matched control subjects, during five minutes. Artefact-free epochs were selected for the non-linear analysis. In all MEG channels, the AD patients had lower complexity than control subjects. In 77 of them the differences were statistically significant (p < 0.01). These preliminary results suggest that cognitive dysfunction in AD is associated with a decreased complexity in certain regions of the brain
Keywords :
cognition; diseases; magnetoencephalography; medical signal processing; Alzheimer disease; MEG; artefact-free epochs; brain; cognitive dysfunction; decreased Lempel-Ziv complexity; magnetoencephalogram background activity; nonlinear analysis; whole-head magnetometer; Alzheimer´s disease; Degenerative diseases; Dementia; Electroencephalography; Magnetic analysis; Magnetometers; Neuroimaging; Senior citizens; Telecommunications; Testing;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615472
