Title :
Study of HIV Variability based on Genomic Signal Analysis of Protease and Reverse Transcriptase Genes
Author :
Cristea, P.D. ; Tuduce, Rodica Aurora ; Otelea, D.
Author_Institution :
Biomed. Eng. Center, Univ. Politehnica of Bucharest
Abstract :
The conversion of genomic sequences into digital genomic signals offers the possibility to use signal processing methods for the analysis of genomic information. The study of genomic signals reveals local and global features of chromosomes that would be difficult to identify by using only the symbolic representation used in genomic data bases. The paper presents a study of the HIV protease (PR) and reverse transcriptase (RT) genes by combining standard nucleotide sequence analysis with IT techniques based on the genomic signal approach. Cumulated and unwrapped phases of genomic signals are analyzed to characterize the variability of clade F HIV-1 strains isolated in Romania
Keywords :
cellular biophysics; enzymes; genetics; medical signal processing; microorganisms; molecular biophysics; HIV variability; chromosomes; clade F HIV-1 strains; digital genomic signals; genomic sequences; genomic signal analysis; nucleotide sequence analysis; protease transcriptase genes; reverse transcriptase genes; signal processing; Bioinformatics; Biological cells; Capacitive sensors; DNA; Genomics; Human immunodeficiency virus; Proteins; Sequences; Signal analysis; Signal processing;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615544
