Title :
Mixture feature selection strategy applied in cancer classification from gene expression
Author :
Jin, Xing ; Deng, Yufeng ; Zhong, Yixin
Author_Institution :
Beijing Univ. of Posts & Telecommun.
Abstract :
Recently, cancer classification based on gene expression has been developed. This gives a hope for the discrimination of cancer to a more systematic direction. However, there´re many challenges existing in the new method. Maybe the most important one is the unbalance that so few training samples exist compared to so huge genes been collected. So feature selection becomes one center problem of the cancer classification. A novel mixture feature selection strategy has been proposed in this paper, it make use of the characters of filter and wrapper, and synthesis three feature selection methods: Pearson correlation analysis, Relief-F and SVM
Keywords :
cancer; cellular biophysics; correlation methods; genetics; medical diagnostic computing; molecular biophysics; support vector machines; Pearson correlation analysis; Relief-F; SVM; cancer classification; filter; gene expression; mixture feature selection strategy; wrapper; Biological tissues; Bones; Cancer; DNA; Filters; Gene expression; Machine learning; Monitoring; Support vector machine classification; Support vector machines; Feature selection; Pearson correlation analysis; Relief-F; SVM; cancer classification;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615547