Title :
Loureirin B: An Effective Component in Dragon´s Blood Modulating Sodium Currents in TG Neurons
Author :
Liu, Xiangming ; Yin, Shijin ; Chen, Su ; Ma, Quanshun
Author_Institution :
Dept. of Biomed. Eng., South-Central Univ. for Nat., Hubei
Abstract :
To test, analyze and express the relationship between the pharmacological effect of traditional chinese medicine (TCM) dragon´s blood and that of its component loureirin B, specify an operational definition for effective component from raw drug of TCM. Using the whole-cell patch-clamp technique, the effects of dragon´s blood and its component loureirin B on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in trigeminal ganglion (TG) neurons were observed. The results show that both dragon´s blood and loureirin B suppressed two types of peak sodium currents in a dose-dependent way. 0.1% dragon´s blood and 0.2mmol/L loureirin B affected the activation and inactivation of sodium channels. The results further prove the analgetic mechanism of dragon´s blood interfering with the nociceptive transmission. According to the above definition, loureirin B is the effective component in dragon´s blood modulating sodium currents in TG neurons
Keywords :
bioelectric phenomena; biomembrane transport; drugs; neurophysiology; sodium; Na; TG neurons; analgetic mechanism; dragon blood; loureirin B; nociceptive transmission; pharmacological effect; tetrodotoxin-resistant sodium currents; tetrodotoxin-sensitive sodium currents; traditional chinese medicine; trigeminal ganglion neurons; whole-cell patch-clamp technique; Biomedical engineering; Biomedical measurements; Blood; Central nervous system; Drugs; Medical tests; Medical treatment; Neurons; Pain; Raw materials;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615588
