Title :
Clinical usefulness of amifostine (YM-08310, WR-2721) as a radioprotective agent
Author :
Takahashi, Iku ; Niibe, Hideo ; Mitsuhashi, Norio ; Nagai, Teruo
Author_Institution :
Dept. of Radiol., Gunma Univ. Sch. of Med., Maebashi, Japan
Abstract :
Radioprotective effects of amifostine were established for acute radiation injury using mucositis in the oral cavity and diarrhea as an index. For chronic radiation injury, radioprotective effects were suggested by the changes in the uptake of Ga-67 citrate in the irradiated salivary glands. Slight adverse reactions appeared, and radioprotective effects on the tumor tissue were not apparent. These results suggested that amifostine can be used as a radioprotective agent in clinical use.<>
Keywords :
radiation protection; WR-2721; YM-08310; acute radiation injury; amifostine; chronic radiation injury; diarrhea; irradiated salivary glands; mucositis; oral cavity; radioprotective agent;
Conference_Titel :
Engineering in Medicine and Biology Society, 1988. Proceedings of the Annual International Conference of the IEEE
Conference_Location :
New Orleans, LA, USA
Print_ISBN :
0-7803-0785-2
DOI :
10.1109/IEMBS.1988.95369
