Title :
Using CellML in Computational Models of Multiscale Physiology
Author :
Nickerson, David ; Hunter, Peter
Author_Institution :
Inst. of Bioengineering, Auckland Univ.
Abstract :
A computational modeling framework is presented which enables the integration of multiple physics and spatial scales in models of physiological systems. A novel aspect of the framework is the use of CellML to specify all model and simulation specific mathematical equations including cellular models and material constitutive relationships. Models of cardiac electromechanics at cellular, tissue, and organ spatial scales are used to illustrate the developed and implemented framework and other applications are discussed
Keywords :
bioelectric phenomena; biological organs; biological tissues; biomechanics; cardiology; cellular biophysics; medical computing; physiological models; CellML; cardiac electromechanics; cellular models; cellular spatial scale; computational models; material constitutive relationships; multiple physics; multiscale physiology; organ spatial scale; physiological systems; tissue spatial scale; Biological system modeling; Biomedical engineering; Calcium; Computational modeling; Equations; Heart; Mathematical model; Physics; Physiology; Proteins;
Conference_Titel :
Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the
Conference_Location :
Shanghai
Print_ISBN :
0-7803-8741-4
DOI :
10.1109/IEMBS.2005.1615884
