Title :
Lab on a Chip Sensor Platform for Explosives and CBW Toxin Detection
Author :
Collins, G.E. ; Haes, A. ; Lu, Q. ; Giordano, B.
Author_Institution :
Naval Res. Lab.
Abstract :
There has been significant interest in the adaptation of lab on a chip devices for the separation and detection of chemical and biological toxins. Potential toxic and/or hazardous analytes of concern in our program include BWA protein toxins,e.g., SEB and ricin, ingestible CW toxins, e.g. alkaloids and rat poisons, and nitroaromatic explosives indicative of IED´s. Discussion will center around our efforts to enhance sensitivity and selectivity on a microchip by incorporation of micro-solid-phase extraction, microchip bubble-cell long pathlength UV detection, organically-modified sol-gel materials for electrochromatography, protein recognition aptamers, and microfluidic-based displacement immunoassays
Keywords :
biohazards; biological techniques; chemical hazards; chemical sensors; chromatography; explosives; lab-on-a-chip; microfluidics; microsensors; proteins; sol-gel processing; BWA protein toxins; CBW toxin detection; alkaloids; biological toxin separation; chemical toxin detection; electrochromatography; explosives detection; hazardous analytes; lab on a chip sensor; microchip bubble-cell long pathlength UV detection; microchip selectivity; microchip sensitivity; microfluidic-based displacement immunoassays; microsolid-phase extraction; nitroaromatic explosives; organically-modified sol-gel materials; protein recognition aptamers; rat poisons; ricin; alkaloids; antibody; aptamer; capillary electrophoresis; displacement immunoassay; explosives; lab on a chip; microchip; ricin; staphylococcus entertoxin B;
Conference_Titel :
Measurement Systems for Homeland Security, Contraband Detection and Personal Safety, Proceedings of the 2006 IEEE International Workshop on
Conference_Location :
Alexandria, VA
Print_ISBN :
1-4244-0240-9
DOI :
10.1109/MSHS.2006.314338
