Synchronized Control for Circadian Rhythm Based on the Central Clock Model of Drosophila

Author

Katakura, Yuta ; Ohmori, Hiromitsu

Author_Institution

Graduate Sch. of Sci. & Technol., Keio Univ., Kanagawa

fYear

2006

Firstpage

2358

Lastpage

2361

Abstract

Circadian rhythm governed by an oscillating set of genes called the central clock has become an important concern in biology, and it is said that to restore an altered rhythm is a goal of cancer therapy beyond the destruction of tumor cells. In this paper, we study the central clock model of drosophila, which is a nonlinear oscillator model. We propose a close-loop control based on flatness-based adaptive control, an open-loop control, to achieve circadian rhythm restoration

Keywords

adaptive control; biocontrol; cancer; circadian rhythms; closed loop systems; nonlinear control systems; open loop systems; synchronisation; tumours; cancer therapy; central clock model; circadian rhythm restoration; close-loop control; drosophila; flatness-based adaptive control; nonlinear oscillator model; open-loop control; synchronized control; tumor cells; Biological system modeling; Cancer; Cells (biology); Centralized control; Circadian rhythm; Clocks; Medical treatment; Open loop systems; Synchronization; Tumors; Circadian rhythm; Nonlinear system;

fLanguage

English

Publisher

ieee

Conference_Titel

SICE-ICASE, 2006. International Joint Conference

Conference_Location

Busan

Print_ISBN

89-950038-4-7

Electronic_ISBN

89-950038-5-5

Type

conf

DOI

10.1109/SICE.2006.314985

Filename

4108033