Title :
Synchronized Control for Circadian Rhythm Based on the Central Clock Model of Drosophila
Author :
Katakura, Yuta ; Ohmori, Hiromitsu
Author_Institution :
Graduate Sch. of Sci. & Technol., Keio Univ., Kanagawa
Abstract :
Circadian rhythm governed by an oscillating set of genes called the central clock has become an important concern in biology, and it is said that to restore an altered rhythm is a goal of cancer therapy beyond the destruction of tumor cells. In this paper, we study the central clock model of drosophila, which is a nonlinear oscillator model. We propose a close-loop control based on flatness-based adaptive control, an open-loop control, to achieve circadian rhythm restoration
Keywords :
adaptive control; biocontrol; cancer; circadian rhythms; closed loop systems; nonlinear control systems; open loop systems; synchronisation; tumours; cancer therapy; central clock model; circadian rhythm restoration; close-loop control; drosophila; flatness-based adaptive control; nonlinear oscillator model; open-loop control; synchronized control; tumor cells; Biological system modeling; Cancer; Cells (biology); Centralized control; Circadian rhythm; Clocks; Medical treatment; Open loop systems; Synchronization; Tumors; Circadian rhythm; Nonlinear system;
Conference_Titel :
SICE-ICASE, 2006. International Joint Conference
Conference_Location :
Busan
Print_ISBN :
89-950038-4-7
Electronic_ISBN :
89-950038-5-5
DOI :
10.1109/SICE.2006.314985
